Ngwá ọgwụ na-egbu egbu bụ otu ìgwè ọgwụ ndị na-eme iji gbochie ma ọ bụ na-egbochi usoro nke ịmepụta sel sel na uto nke anụ ahụ jikọrọ ọnụ.
Kedu mgbe a na-ahazi cytostatics?
Akụkụ bụ isi nke ngwa ọgwụ ndị a jụrụ bụ ịgwọ ụbụrụ na-arịa ọrịa bụ nke a na-ejikọta nkeji sel na-enweghị ike ịchịkwa (cancer, leukemia , lymphomas, wdg).
N'ebe dị nta karị, mmetụta nke ọgwụ ọjọọ dị na otu a na-edozi mkpụrụ ndụ nke ụmị ọkpụkpụ, akpụkpọ anụ, akpụkpọ anụ mucous, epithelium nke akụkụ eriri afọ. Nke a na - enye ohere iji ọgwụ cytostatics na - ebute ọrịa na - akpata ọrịa (arthritis rheumatoid, scleroderma, lupus nephritis, ọrịa Goodpasture, systemic lupus erythematosus, wdg).
Dịka akụkụ nke ọgwụgwọ siri ike, a pụrụ iji ọgwụ ọjọọ na-eme ihe n'ụzọ dị ọnụ n'ụdị mbadamba, capsules, ma ọ bụ dị ka injections (intravenous, intra-arterial, intraluminal, intravitreal). Oge nke usoro ọgwụgwọ ahụ kpebiri site na oke ọrịa ahụ, ịdị irè na nkwụsị nke ọgwụ.
Ndepụta nke ọgwụ ọjọọ cytotoxic
A na-ekekọta ndị Cytostatics maka ebumnuche nke inye iwu, na nhazi a bụ ọnọdụ, n'ihi na ọtụtụ ọgwụ ndị dị n'otu otu nwere usoro pụrụ iche nke ọrụ ma dị irè megide ụdị nrịanrịa ọjọọ ọ bụla dị iche iche. Nke a bụ ndepụta kachasị nke aha ọgwụ ndị na-eme ka cytotoxic:
1. Ngwakọta ọgwụ ndị na-egbu egbu:
- alkylsulfonates (Busulfan, Treosulfan);
- ethylenimines (Thiotepa);
- ihe mgbakwasị nke nitrosoureas (Nimustine, Lomustine, Carmustine, Mystophoran, Streptozotocin);
- chloroethylamines (Chlorambucil, Ifosfamide, Bendamustine, Cyclophosphamide, Melphalan, Trophosphamide).
2. Alkaloids nke osisi si:
- podophyllotoxins (Teniposide, Etoposide);
- taxanes (docetaxel, paclitaxel);
- vinaalkaloids (Vindesin, Vincristine, Vinblastine, Vinorelbine).
3. Antimetabolites:
- ndị na-agba mbọ na folic acid (Ralitrexed, Methotrexate);
- Ndi antagonists Purine (Cladribine, Fludarabine, Pentostatin, Thioguanine);
- adtagonists nke pyrimidine (cytarabine, capecitabine, gemcitabine, fluorouracil).
4. Ọgwụ nje na ọrụ antitumor:
- anthracycline (Doxorubicin, Daunorubicin, Epirubicin, Idarubicin, Mitoxantrone);
- ọgwụ nje ndị ọzọ na-emepụta ọgwụ (antitumoral, bleomycin, plikamycin, dactinomycin).
5. Ndị ọzọ cytostatics:
- ihe ndị sitere na camptothecin (Irinotecan, Topotecan);
- ihe mgbakwasị nke platinum (Cisplatin, Carboplatin, Oxaliplatin);
- ndị ọzọ (Temozolomide, Altrethamine, Estramustine, Amsacrine, L-asparaginase, Dacarbazine, Hydroxycarbamide, Procarbazine).
6. Mgboclonal antibodies (Trastuzumab, Ederkolomab, Rituximab).
7. Homonụ Cytostatic:
- antiandrogens (cyproterone acetate, bicalutamide, flutamide);
- progestins (Medroxyprogesterone acetate, Megestrol acetate);
- estrogens (Polyestradiol, Phosphastrol);
- antiestrogens (Toremifene, Tamoxifen, Droloxifene);
- ndị na-emepụta aromatal (Anastrozol, Formestan, Exemestane).
- LH-RH agonists (Gocerelin, Buserelin, Leiprolein acetate, Tryptorelin).
Ndị na-enye ọgwụ na-egbu egbu maka pancreatitis
Na ọrịa siri ike, a pụrụ iji cytostatics (dịka, fluorouracil) maka ọgwụgwọ. A na - ejikọta usoro nke ọgwụ ndị a na ike ha imechi ọrụ nhụjuanya nke mkpụrụ ndụ pancreatic.
Mmetụta dị n'akụkụ nke Cytostatics
Ụdị mmetụta dị iche iche na ọgwụgwọ nke cytostatics bụ:
- ọnwụ ntutu;
- afọ ọsịsa;
- ihe ngwangwa ;
- nhazi;
- vomiting;
- isi ọwụwa;
- adịghị ike ahụ;
- mmebi nke oge ntoju;
- infertility;
- mmepe nke leukemia, wdg.